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Lanqin Oral Liquid is a Chinese patent medicine which contains Isatidis Radix, Scutellariae Radix, Gardeniae Fructus, Phellodendri Chinensis Cordex and Sterculiae Lychophorae Semen. It is known for the pharmaceutical effect on the upper respiratory tract infection as it is beneficial for relieving the swelling of pharyngeal. In terms of Chinese medicine, it offers a clearing action on heat and toxic materials. According to the principle of Chinese medicine, different diseases can be treated by the same therapy as long as they have the same syndrome. Based on this unique diagnosis and treatment approach, Lanqin Oral Liquid was applicable to diseases with syndrome of excessive heat in lung and stomach. It was therefore commonly be used in the therapeutic approach towards hand, foot and mouth disease as well. However, no systematic evaluation had yet been done to verify this Chinese patent medicine on the efficacy and clinical safety for the disease. In order to achieve the manner of evidence-based medicine, this study had adopted a systematic review and Meta-analysis to evaluate the efficacy and safety of Lanqin Oral Liquid in the treatment of hand, foot and mouth disease. All related randomized controlled trials(RCT) were searched in the following data bases: CNKI, WanFang, VIP, SinoMed, Cochrane Library and PubMed. Based on the method provided by the Cochrane collaboration, the study assessed the quality of papers selected and RevMan 5.3 software was used to perform Meta-analysis. Totally 24 studies were included with 3 491 sample size, which 1 826 cases were treatment group and 1 665 cases were control group. From the results of Meta-analysis, the total effective rate of combination of Lanqin Oral Liquid and Western medicines shown better than Western medicine alone in the treatment for hand, foot and mouth di-sease, but mild adverse event were also found(RR=1.20,95%CI[1.16,1.23],P<0.000 01). Incidence of adverse reaction between experimental and control group was statistically insignificant(RR=1.16, 95%CI[0.79, 1.70], P=0.45). No conclusion was able to made in terms of the remission time of clinical symptoms, as the studies included were not qualified for Meta-analysis. As a matter of fact, the number of existing studies related to the Lanqin Oral Liquid were limited with poor quality as well. In other words, high quality studies were essential to further evaluate the efficacy and safety of Lanqin Oral Liquid.
Subject(s)
Humans , Drugs, Chinese Herbal , Hand, Foot and Mouth Disease , Medicine, East Asian Traditional , Nonprescription Drugs , Research DesignABSTRACT
OBJECTIVE： To systematically evaluate the efficacy and safety of Lanqin oral liquid in the treatment of herpangina in children. METHODS： Randomized controlled trials （RCTs） involving Lanqin oral liquid or routine symptomatic treatment combined with Lanqin oral liquid （trial group） versus routine treatment （control group） in the treatment of pediatric herpangina were retrieved from PubMed， Embase， CBM， CNKI， Wanfang database， VIP database， etc. Meta-analysis was performed by using Rev Man 5.3 software after literature screening， data extraction and quality evaluation with Cochrane system evaluator manual 5.1.0. RESULTS： A total of 11 RCTs were included， involving 1 204 patients. Meta-analysis showed that total response rate [RR＝1.17， 95％CI（1.10， 1.24）， P＜0.000 01]， fade time of herpes [MD＝－2.17， 95％CI（－2.63， －1.72）， P＜0.000 01] and fade time of fever [MD＝－1.52， 95％CI（－1.72， －1.31）， P＜0.000 01] in trial group was significantly higher than in control group. There was no statistical significance in the incidence of ADR between 2 groups [RR＝1.00， 95％CI（0.52， 1.93）， P＝1.00]. Subgroup analysis based on rehydration symptomatic treatment showed that without rehydration， fade time of herpes in trial group was significantly shorter than control group [MD＝－1.64， 95％CI （－2.03， －1.26）， P＜0.000 01]； with rehydration， fade time of herpes in trial group was significantly shorter than control group [MD＝－2.79， 95％CI（－2.97， －2.61），P＜0.000 01]. CONCLUSIONS： Lanqin oral liquid can effectively improve therapeutic efficacy of herpangina patients， effectively shorten fade time of fever and herpes， without increasing the occurrence of ADR.
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To systematically assess the effectiveness and safety of lanqin oral liquid for the treatment of chronic pharyngitis. Databases including PubMed, Embase, The Cochrane Library, SinoMed, CNKI, VIP and Wanfang Data were electronically searched in March 2017 for randomized controlled trials(RCTs) on Lanqin oral liquid for the treatment of chronic pharyngitis. Two authors independently screened literature, extracted data, and assessed the risk of bias of included studies. Then, meta-analysis was performed by RevMan 5.3 software. Thirteen RCTs were included with a total of 1 642 patients. The results of meta-analysis showed that the efficiency of lanqin oral liquid were significantly higher than those of conventional therapy or other treatments; Besides, lanqin oral liquid could significantly increase the amount of IL-2 further more, lanqin oral liquid could significantly reduce the amount of TNF-α. Safety of lanqin oral liquid was not concerned by any RCT. Current evidence indicates that the efficiency of lanqin oral liquid was better than conventional therapy or other treatments. Due to the poor quality of the included studies, the above conclusion should be verified by more RCTs of high quality.
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objective: To analyze Lanqin Oral Liquid (LOL) combined with nutritional therapy in the treatment of patients with hand foot mouth disease (HFMD). Methods: A total of 120 patients with HFMD in the Third Hospital of Qinhuangdao were randomly divided into observation group and control group, each of 60 cases. The patients in observation group were given routine treatment plus LOL combined with parenteral nutrition therapy, and the patients in control group were only given conventional treatment. The blood immunoglobulin IgG protein, total protein, total white cell count, and creatine kinase isoenzyme changes of children in two groups before treatment and 7 d after treatment were compared, and weight gain, hospitalization expenses, and hospitalization days of difference of children in two groups were also compared. Results: The IgG in blood of children in observation group was significantly higher than that in the control group (P < 0.05), and WBC and CK-MB in blood of children in observation group were significantly lower than that in the control group (P < 0.05). The weight gain of the observation group was significantly higher than that in the control group (P < 0.05); The length of hospital stay in the observation group was shorter than that in the control group (P < 0.05). Conclusion: LOL combined with parenteral nutrition can promote the rehabilitation of children with HFMD and improve treatment outcome.
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Objective To systematically evaluate the clinical efficacy of Lanqin Oral Liquid(LOL)and ribavirin on infantile hand-foot-mouth disease(HFMD).Methods The randomized controlled trials(RCT)of LOL and ribavirincombined for treating HFMD were retrieved from EMbase, PubMed, CNKI, CBM and VIP(from establish to Oct 2014), the methodological quality of included literature was evaluated, and data analyses were performed with RevMan 5.2 software.Results Fifteen studies involving 2 016 patients were ultimately identified.The meta-analysis results showed that the effective rate of LOL group was superior to that of the control,OR(95%CI)was 5.80 (3.94, 8.52), and there were significant differences in the antifebrile time, erythra regression time, herpes regression time and oral ulcer regression time between the groups,MD (95%CI): -1.29 (-1.45,-1.13), -1.88 (-2.44,-1.33), -1.57 (-2.36,-0.78), -1.57 (-2.07,-1.08), respectively. Conclusion Based on the present clinical evidence, the meta-analysis results indicate that LOL and ribavirin treating HFMD is effective and safe. However, due to the uneven quality of these included studies, this conclusion need more large sample size and high-quality clinical RCTs to be confirmed.
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Objective To observe the therapeutic effect of Lanqin oral liquid on the wind heat syndrome of the fever caused by viral upper respiratory tract infection.Methods 130 cases from our hospital of the fever(wind heat syndrome)caused by viral upper respiratory tract infection,including 20 confirmed cases of H1N1 influenza A,8 suspected cases,and 41 clinically diagnosed cases were treated with Lanqin oral liquid,for 3 days'treatment and oneday follow-up,the rate of instant antipyretic effect and the antipyretic time were observed.Results The fever was reduced in 39 cases(30.0％)and 118 cases(90.8％),within 4h and 72h after medication respectively.The average antipyretic time was 20.5h.Conclusion Lanqin oral liquid can treat the fever(wind heat syndrome)caused by viral upper respiratory tract infection effectively.
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Objective:To simultaneously determine the contents of berberine hydroehloride and baicalin in Lanqin Oral Liquid via an HPLC method.Method:The HPLC with a Cl8 column(4.6?150 mm,5?m)was used.The mobile phases were as follows:the methanol-0.5%orthophosphoric acid(0～16.5 min,methanol 38%～40%,V=1 ml/min;16.8～18 min,methanol 99%,V=1.6ml/min;18.1～22min,methanol 38%,V=1.6ml/min;22.1～23 min,methanol 38%,V=1 ml/min.).The wavelength for detection was located at 275nm.Result:The linear ranges of berberine hydrochloride and baicallin were 6.8～65.28?g/ml and 31.2～299.52?g/ml,respectively,both showing a good linar relationship,and the average spotting recoveries were higher than 97.0%.The coefficient of variation was smaller than 2.0%.Con-clusion:The method is convenient and can be used for controlling the quality of Lanqin Oral Liquid.